Kodi zimayambitsa psoriasis ndi chiyani?

Zomwe zimayambitsa psoriasis zimaphatikizapo majini, chitetezo cha mthupi, chilengedwe ndi zinthu zina, ndipo pathogenesis yake sichidziwika bwino.

 1. Zinthu zachibadwa

Kafukufuku wambiri wasonyeza kuti majini amachititsa kuti pathogenesis ya psoriasis iwonongeke. Mbiri ya banja la matendawa ndi 10% mpaka 23.8% ya odwala ku China komanso pafupifupi 30% m'maiko akunja.Mwayi wokhala ndi mwana wodwala psoriasis ndi 2% ngati palibe kholo lomwe lili ndi matendawa, 41% ngati makolo onse ali ndi matendawa, ndipo 14% ngati kholo limodzi lili ndi matendawa.Kafukufuku wa mapasa okhudzana ndi psoriasis awonetsa kuti mapasa a monozygotic ali ndi mwayi wa 72% wokhala ndi matendawa panthawi imodzimodzi ndipo mapasa a dizygotic ali ndi mwayi wa 30% wokhala ndi matendawa nthawi imodzi. Zoposa 10 zomwe zimatchedwa susceptibility loci zadziwika zomwe zimagwirizana kwambiri ndi chitukuko cha psoriasis.

2. Zinthu zoteteza thupi ku matenda

 Kuyambitsa kwachilendo kwa T-lymphocytes ndi kulowa mu epidermis kapena dermis ndizofunikira kwambiri pathophysiological ya psoriasis, zomwe zimasonyeza kukhudzidwa kwa chitetezo cha mthupi pakukula ndi kupitirira kwa matendawa.Kafukufuku waposachedwapa wasonyeza kuti IL-23 kupanga maselo dendritic ndi maselo ena antigen-presenting (APCs) imapangitsa kusiyana ndi kuchuluka kwa CD4+ wothandizira T lymphocytes, Th17 maselo, ndi osiyana okhwima Th17 maselo akhoza secrete zosiyanasiyana Th17-ngati ma cell zinthu monga monga IL-17, IL-21, ndi IL-22, zomwe zimalimbikitsa kuchulukana kwambiri kwa maselo opangira keratin kapena kuyankha kotupa kwa ma synovial cell. Choncho, maselo a Th17 ndi IL-23 / IL-17 axis angathandize kwambiri pathogenesis ya psoriasis.

3. Zinthu Zachilengedwe ndi Zamagetsi

Zinthu zachilengedwe zimagwira ntchito yofunika kwambiri poyambitsa kapena kukulitsa psoriasis, kapena kukulitsa matendawa, kuphatikizapo matenda, kupsinjika maganizo, zizoloŵezi zoipa (mwachitsanzo, kusuta fodya, kuledzera), kupwetekedwa mtima, ndi machitidwe a mankhwala ena.Kuyamba kwa pitting psoriasis nthawi zambiri kumagwirizanitsidwa ndi matenda aakulu a streptococcal a pharynx, ndipo mankhwala odana ndi matenda amatha kupititsa patsogolo ndi kuchepetsa kapena kuchepetsa zotupa pakhungu. Kupsinjika maganizo (monga kupsinjika maganizo, kusokonezeka kwa kugona, kugwira ntchito mopitirira muyeso) kungayambitse psoriasis, kuwonjezereka kapena kubwereza, ndipo kugwiritsa ntchito malingaliro othandizira maganizo kungachepetse vutoli. Zimapezekanso kuti matenda oopsa, matenda a shuga, hyperlipidemia, matenda a mitsempha ya m'mitsempha komanso makamaka metabolic syndrome ali ndi vuto lalikulu pakati pa odwala psoriasis.