Zomwe zimayambitsa psoriasis zimakhudza majini, chitetezo chamthupi, zachilengedwe ndi zina, ndipo matenda ake sanadziwike bwino.
1. Zinthu zokhudzana ndi majini
Kafukufuku wambiri wasonyeza kuti majini ndi omwe amachititsa kuti matenda a psoriasis ayambe. Mbiri ya banja la matendawa imayambira pa 10% mpaka 23.8% ya odwala ku China ndi pafupifupi 30% m'maiko akunja.Mwayi wokhala ndi mwana wokhala ndi psoriasis ndi 2% ngati makolo onse awiri alibe matendawa, 41% ngati makolo onse awiri ali ndi matendawa, ndi 14% ngati kholo limodzi lili ndi matendawa.Kafukufuku wa mapasa ogwirizana ndi psoriasis wasonyeza kuti mapasa a monozygotic ali ndi mwayi wa 72% wokhala ndi matendawa nthawi imodzi ndipo mapasa a dizygotic ali ndi mwayi wa 30% wokhala ndi matendawa nthawi imodzi. Malo opitilira 10 otchedwa susceptibility loci apezeka omwe amagwirizana kwambiri ndi kukula kwa psoriasis.
2. Zinthu zomwe zimayambitsa chitetezo chamthupi
Kuyambitsa kwachilendo kwa ma T-lymphocyte ndi kulowa mu epidermis kapena dermis ndi zizindikiro zofunika kwambiri za matenda a psoriasis, zomwe zikusonyeza kuti chitetezo cha mthupi chimakhudzidwa pakukula ndi kupita patsogolo kwa matendawa.Kafukufuku waposachedwapa wasonyeza kuti kupanga kwa IL-23 ndi maselo a dendritic ndi maselo ena omwe akuwonetsa ma antigen (APCs) kumayambitsa kusiyana ndi kufalikira kwa ma lymphocyte othandizira a CD4+ T, maselo a Th17, ndi maselo a Th17 okhwima omwe asiyanitsidwa amatha kutulutsa zinthu zosiyanasiyana za maselo ofanana ndi a Th17 monga IL-17, IL-21, ndi IL-22, zomwe zimapangitsa kuti maselo opanga keratin achuluke kwambiri kapena kuyankhidwa kwa maselo a synovial. Chifukwa chake, maselo a Th17 ndi IL-23/IL-17 axis zitha kukhala ndi gawo lofunikira pakukula kwa psoriasis.
3. Zinthu Zachilengedwe ndi Kagayidwe kachakudya
Zinthu zachilengedwe zimathandiza kwambiri kuyambitsa kapena kukulitsa psoriasis, kapena kutalikitsa matendawa, kuphatikizapo matenda opatsirana, kupsinjika maganizo, zizolowezi zoipa (monga kusuta fodya, uchidakwa), kuvulala, komanso momwe mankhwala ena amakhudzira munthu.Kuyamba kwa psoriasis ya pitting nthawi zambiri kumagwirizanitsidwa ndi matenda a streptococcal a pakhosi, ndipo chithandizo choletsa matenda chingayambitse kusintha ndi kuchepetsa kapena kumasula zilonda za pakhungu. Kupsinjika maganizo (monga kupsinjika maganizo, matenda ogona, kugwira ntchito mopitirira muyeso) kungayambitse psoriasis, kukulirakulira kapena kubwereranso, ndipo kugwiritsa ntchito mankhwala othandizira maganizo kungathandize kuchepetsa vutoli. Zapezekanso kuti kuthamanga kwa magazi, matenda a shuga, hyperlipidemia, matenda a mitsempha ya mtima komanso makamaka matenda a metabolic syndrome ndi matenda ofala kwambiri pakati pa odwala a psoriasis.
Nthawi yotumizira: Mar-17-2023
